National Dental Examining Board of Canada (NDEB) Practice Exam

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Prepare for the National Dental Examining Board of Canada (NDEB) Test. Study with flashcards and multiple choice questions, each question offers hints and detailed explanations. Achieve success in your exam!

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Which penicillin is least resistant to the level of acidity in the stomach?

  1. Ampicillin

  2. Amoxicillin

  3. Benzylpenicillin

  4. Cloxacillin

The correct answer is: Benzylpenicillin

The reason why the other options are incorrect is because ampicillin, amoxicillin, and cloxacillin are all semi-synthetic penicillins and thus have been chemically modified to be more resistant to stomach acid. Cloxacillin, in particular, has a side chain that makes it more resistant to stomach acid. However, benzylpenicillin is not a semi-synthetic penicillin and has no additional modifications to make it more resistant to stomach acid. Therefore, it is the least resistant to the acidic conditions in the stomach.